Perhaps you should change careers? Get a job where you interact with people in a positive way - for instance become a teacher, work in a kindergarden or similar.
Big changes are in general a bad idea when it comes to people struggling with clinical depression. Developing a healthy daily rhythm (sleep, food, exercise), dropping drugs and limiting alcohol intake are the first lifestyle changes a depressed person should make.
And don't forget depression is an illness. Medical help is a must. There's no healing without medical help.
