It's about finding a balance. I can't stand a cluttered desk, but I'm a cluttered person, generally. I take care of it by swiping everything off my desk once every other week and into the bin. If I can't immediately think of a reason to save something from the carnage, it's probably not important at all anymore.

I've yet to be burned by this and I take the approach to my closets at home, too. While spring cleaning, if I can't remember seeing some item in the last year, it goes to goodwill. My wife used to freak out about sentimental things, but she's come around. They're just things. If they're really that sentimental, put them someplace you can admire them every day.