Intersting though: sucralose is just normal saccharose, but with a hydrogen substituted with chlorine. One would think it should be the least dangerous one, due to being so similar to a natural molecule.
This is like changing the input to a hash function by just one and being surprised the output is so different.
That said, your confusion probably originated with Splenda’s “tastes like sugar ‘cause it’s made from sugar” marketing, which was ruled to be misleading.
Yet, medicines of similar structure and minor substitutions all have very similar profile, otherwise they would not havve been unified in different classes (say, benzodiazepines).