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There isn't really a meaningful difference; either way the immune system is responding to a protein and "remembering" it.

mRNA breaks down within a few days, by which point spike protein production by your cells has stopped, and the spike proteins themselves break down within a few weeks.

Inactivated virus would be broken down and excreted within a similar timeframe or faster; it's the immune system memory of the proteins that it encountered that persists.



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