Every improvement has, at the very least, its Luddite cost. It forces some people to change, and some of those people won’t like that.
Not disadvantage, trade-off cost. Someone, no doubt, lost business selling quack cures.
Is your point that there are technologies with only benefits?
Invention of antibiotics, its use and abuse increased bacterial resistance to them.
Every improvement has, at the very least, its Luddite cost. It forces some people to change, and some of those people won’t like that.