I have been using Bvckup 2 to backup primarily to my Synology Nas. It correctly identifies that the destination directory is a SAMBA v3.1 mount, and treats it as NTFS.

I actually love using it for my Synology as it has the ability to do Delta Copying. Some of my folders contain VM's and VeraCrypt drives, and it is very fast when it comes to sending delta copies. It still has to read the file on the destination to determine what to write, but that only becomes apparent on large files. I think you may lose some features since it is a mounted network drive(mainly limitations to SAMBA), but I have had no issues with it.

Scanning remote files is fast, if the contents or timestamps haven't changed I've seen it scan over 600K files in a couple of minuets (duplicacy backup, in the process of moving to a new hard drive and need to store it temporarily on the Nas).

I've been playing with doing file change detection based on NTFS journals. There are some caveats, but it looks very promising. It's O(1) basically instead of O(file-size).

It works really well with Synology boxes. It also has quite a few Synology-specific tweaks, including support for their weird quirk of rounding up file timestamps to the nearest second and then subtracting a millisecond from it.