Hah, neat, I had just ran into that chemical a few days ago in my own research, for similar reasons.
Right now I'm trying diosmin, under a parallel theory: that it protects, increases tone of, and stimulates growth of, lymphatic channels. (Amusingly enough, the main on-label use is for hemorrhoids.)
I picked this avenue of research since my own body seems to have a rather sucky lymphatic system: I constantly get fungal infections (but not bacterial/viral ones); I've had middle-ear infections several times in my life, once leading to labyrinthitis; I have a family history of lymphedema and varicose veins; and no matter how well I maintain my oral hygiene and stay hydrated, I still get dental carries and periodontal abscesses. (Also, oddly enough, all my hair grows really fast; and directly atop lymph nodes, I will get ingrown "compound" hairs (pili multigemni). Both sort of suggest an eccrine system trying to expel debris that isn't getting cleared any other way.)
So far I can at least say that it unplugs my sinuses (in a different way than a decongestant—gunk ends up in my throat, and my sinuses don't dry out), makes me experience heartburn for the first time since I was a child (probably a bile duct thing), and makes it actually painful to sit with my legs folded under me for more than a few minutes, whereas I used to be able to do that for hours (which was probably a bad thing with a high risk of DVT anyway.) So it's doing something.
The experiment I really want to try, though, is to combine the diosmin with N-acetylcholine (or any other metabolically-active glutathione precursor.) From what I understand, glutathione is used up by lymphatic processes (at least both of liver xenometabolism and mucus creation.) I expect, without NAC supplementation, it will appear that my body eventually "habituates" to the diosmin and stops doing anything useful.
Edit: one more bonus piece of anecdata—I've gone, on one week of diosmin, from a person who hates being too hot (to the point that I don't enjoy ever getting my face/chest wet in the shower; to the point that I hate drinking coffee/tea just because it's hot) but is fine in the cold (often not bothering to wear a sweater outside in Canadian winter)... to a person who can easily tolerate heat, and gets cold very easily. Very, very bizarre.
casual asides: a local retired GP where I once lived was into herbal supplements. For fungal disorders when all else failed he would frequently push high-concentrate oregano extract. Plus vinpocetine appears to be useful in treating tinnitus.
which suggests this may be something to research (Puritan's Pride online has it). And heat/cold tolerance seems circulation-focused. When growing up I was shuttled between northeast US and frequent sailing trips in SW Florida (where I am now ... snow sucks). Back then 30C seemed hot and sweaty. Now that's just a pleasant day in November. 10C seemed pleasant up north but now 10C in January here requires 2 or more layers. When the physiology stabilizes and acclimates the circulation adjusts.
Hah, neat, I had just ran into that chemical a few days ago in my own research, for similar reasons.
Right now I'm trying diosmin, under a parallel theory: that it protects, increases tone of, and stimulates growth of, lymphatic channels. (Amusingly enough, the main on-label use is for hemorrhoids.)
I picked this avenue of research since my own body seems to have a rather sucky lymphatic system: I constantly get fungal infections (but not bacterial/viral ones); I've had middle-ear infections several times in my life, once leading to labyrinthitis; I have a family history of lymphedema and varicose veins; and no matter how well I maintain my oral hygiene and stay hydrated, I still get dental carries and periodontal abscesses. (Also, oddly enough, all my hair grows really fast; and directly atop lymph nodes, I will get ingrown "compound" hairs (pili multigemni). Both sort of suggest an eccrine system trying to expel debris that isn't getting cleared any other way.)
So far I can at least say that it unplugs my sinuses (in a different way than a decongestant—gunk ends up in my throat, and my sinuses don't dry out), makes me experience heartburn for the first time since I was a child (probably a bile duct thing), and makes it actually painful to sit with my legs folded under me for more than a few minutes, whereas I used to be able to do that for hours (which was probably a bad thing with a high risk of DVT anyway.) So it's doing something.
The experiment I really want to try, though, is to combine the diosmin with N-acetylcholine (or any other metabolically-active glutathione precursor.) From what I understand, glutathione is used up by lymphatic processes (at least both of liver xenometabolism and mucus creation.) I expect, without NAC supplementation, it will appear that my body eventually "habituates" to the diosmin and stops doing anything useful.
Edit: one more bonus piece of anecdata—I've gone, on one week of diosmin, from a person who hates being too hot (to the point that I don't enjoy ever getting my face/chest wet in the shower; to the point that I hate drinking coffee/tea just because it's hot) but is fine in the cold (often not bothering to wear a sweater outside in Canadian winter)... to a person who can easily tolerate heat, and gets cold very easily. Very, very bizarre.