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"Napoleon may have once said “quantity has a quality all its own”."

Nope, It was Stalin who said that in regards to his "meatwave" strategy.


we should be asking if reasoning while speaking is even possible for humans. this is why we have the scientific method and that's why LLMs write and run unit tests on their reasoning. But yeah intelligence is probably in the ear of the believer.


smh. his idea that he both doesn't think anyone has ever thought of "Founder Mode" before while simultaneously thinking that the founders are the ones responsible for a company's success or failure through something like sheer force of will or a better carrot and stick. I donno. Companies are successful mostly because of who they hire... and timing (also known as luck).


every holy grail is 5 years away. i've been reading this for 20 years now.


Honestly IBD is one area where we've made massive progress in the past few decades. We went from having zero biologics (which means your only options were mediocre oral meds, long-term steroid use, or various -ectomies) to having dozens of biologics that each target one of a handful of major inflammatory pathways. Remicade was the first holy grail :)


I started on Remicade, but sadly I was one of the few who didn’t see results and I managed to get a lot sicker while waiting for it to do its thing. I got put on Upadacitinib and so far I feel a lot better, if it keeps working this well then I’m very happy to just have a pill to take daily. It’s pretty new, but from what I’m hearing it’s very effective.


Upadacitinib has been a huge success for someone in my family. Spectacularly effective.

This is after trying the Specific Carbohydrate Diet, 5-ASAs, adalimumab, ustekinumab, and vedolizumab, none of which offered more than minor relief.


Fingers crossed for the new pill! I've also heard that JAK inhibitors work wonder for a lot of people who didn't get results from TNF inhibitors. And it's probably way easier to tinker with the dose if need be :P


i often thing such claims are progress updates from research groups dependent on government grants for funding, so they need to assert they will still need a next round of funding.


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